Great Harbor is situated on the southwestern tip of Cape Cod. This harbor serves as a vital hub for maritime activities, including commercial shipping, recreational boating, and scientific research. Its deep waters and sheltered coves make it an ideal anchorage for boats of various sizes, from fishing vessels to sailboats and yachts. Visitors to Great Harbor can enjoy views of the surrounding coastline, watch boats coming and going, and explore the quaint village of Woods Hole with its charming shops, waterfront restaurants, and historic landmarks. 

Woods Hole is in the town of Falmouth in Barnstable County. It lies at the extreme southwest corner of Cape Cod, near Martha's Vineyard and the Elizabeth Islands.

It is the site of several marine science institutions, including Woods Hole Oceanographic Institution, the Marine Biological Laboratory, the Woodwell Climate Research Center, NOAA's Northeast Fisheries Science Center (which started the Woods Hole scientific community in 1871), the Woods Hole Science Aquarium, a USGS coastal and marine geology center, and the home campus of the Sea Education Association. And the headquarter of the Climate Foundation.

It is also the site of United States Coast Guard Sector Southeastern New England (formerly USCG Group Woods Hole), the Nobska Light lighthouse, and the terminus of the Steamship Authority ferry route between Cape Cod and the island of Martha's Vineyard.

Woods Hole is located at the southwest tip of the town of Falmouth (and of Cape Cod). The term "Woods Hole" refers to a strait named Woods Hole, which separates Cape Cod from the Elizabeth Islands (specifically, Uncatena Island and Nonamesset Island) and which boats, yachts, and small ferries can use to travel between Vineyard Sound and Buzzards Bay. The strait is known for its extremely strong current, approaching four knots.

Much of Woods Hole centers around the enclosed harbor of Eel Pond. The Eel Pond Bridge, a bascule drawbridge at the mouth of the harbor, allows boats to enter and exit the harbor according to a fixed schedule posted on the side of the bridge.

Nobska Light, a lighthouse at Nobska Point, is operated by the United States Coast Guard, and the accompanying house is the home of the commander of the Coast Guard base at Little Harbor.

The local landmark The Knob is a rocky outcropping that overlooks Buzzards Bay and Quisset Harbor. It is a part of the privately owned Salt Pond bird sanctuaries.