Andrews University is located in the Village of Berrien Springs in southwest Michigan. The campus is adjacent to the Saint Joseph River and 12 miles away from the shores of Lake Michigan. South Bend, Indiana, home of the University of Notre Dame, is 25 miles away; thus, some Andrews faculty members hold joint appointments with Notre Dame.

The 1,600-acre campus is officially designated as an arboretum. The campus maintains a variety of indigenous trees, especially around the quad in the center of the campus. The campus is composed of 27 instructional buildings, the Howard Performing Arts Center, an airpark, four residence halls, and four apartment complexes.