Refuge Headquarters is where you can find brochures, maps, and other relevant information before you venture out on refuge lands. This location also offers interpretative opportunities in the Conservation Garden which begins just to the left, or southwest side, of the headquarters building. 

Established to protect a diminished habitat type, bottomland hardwood forest, and support migratory birds, Clarks River National Wildlife Refuge is one of only two refuges fully located and managed in Kentucky.

In 1998, Clarks River National Wildlife Refuge became the 549th National Wildlife Refuge in the Country. Located in far western Kentucky, the refuge encompasses one of the largest remaining bottomland hardwood forest in the region. Bottomland hardwood forests are one of the most biologically productive ecosystems on land. Freshwater mussels, amphibians, fish, and mammals are all found in abundance here. Additionally, migratory songbirds and waterfowl take advantage of this rich habitat on their long flights from nesting to wintering grounds.