Eufaula National Wildlife Refuge was established in 1964, with community support and in cooperation with the U.S. Army Corps of Engineers, to provide habitat for wintering waterfowl and other migratory and resident wildlife.

Eufaula National Wildlife Refuge lies within the historical range of the longleaf pine/wiregrass ecosystem and contains remnant longleaf pine stands. Refuge wetlands, croplands, woodlands, old fields, grasslands, and open water create a mosaic of wildlife-rich habitats that support almost 300 species of birds, 40 species of mammals, and many amphibians, reptiles, and fish.

The main unit of the 11,184-acre refuge is located about 7 miles north of the city of Eufaula, Alabama, along both banks of the Chattahoochee River in southeast Alabama and southwest Georgia.

The refuge headquarters is located eight miles north of Eufaula, Alabama, approximately two miles east of US-431 on AL-165. The office is staffed from 8 am to 4:30 pm (central time), Monday through Friday. The refuge is open daily during daylight hours.