The Reserve’s headquarters are located in the historic Sargent Estate, including a Visitor Center, staff offices, laboratory, education programs, short walking trails, and a picnic area. 

The public is welcome during business hours Monday-Friday from 10:00 am to 4:00 pm.

Waquoit Bay National Estuarine Research Reserve is located on the south shore of Cape Cod, Massachusetts, and contains open waters, salt, and fresh marshes, barrier beaches, sand dunes, rivers, mixed pine and oak forests, and sandplain grasslands. Waquoit Bay, approximately 825 acres, is the dominant water feature and once supported one of the most diverse estuarine fish communities in the state. Waquoit Bay is still important to commercial and recreational shellfish and finfish fisheries.