Myrtle Grove Wildlife Management Area is located in Charles County, Maryland near La Plata. This WMA encompasses the forested bottomlands of Mattawoman Creek and was once home to the Piscataway Indians. The original tract of Myrtle Grove WMA was acquired by the State of Maryland in 1929. This tract included 754 acres in the central portion of the property. Since that time, many additional acquisitions have grown this WMA to 5,190 acres, making it the largest Wildlife Management Area in the Southern Region.

Trails are unmanicured dirt, gravel, or grass that can be rough or muddy and may be unsuitable for some users. Users are not required to stay on trails.​