Peregrine Falcons have used the Crile Building as a nesting and roosting site.

The signature building of the Cleveland Clinic, the Crile Building houses the outpatient services department. Within these 14 stories are doctors’ offices for nearly every medical specialty. Some same-​day surgeries, rehabilitation, and other services also take place in the building. The Crile Building is the first building completed under the Cleveland Clinic Green campus master plan, which Pelli Clarke Pelli Architects also designed.